A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort

A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort

Blog Article

Abstract The men firefighter costume contributing genetic factors of vertigo remain poorly characterized, particularly in individuals of non-European ancestries.Here we show the genetic landscape of vertigo in an Asian population-based cohort.In a two-stage genome-wide association study (Ncase = 6199; Ncontrol = 54,587), we identify vertigo-associated genomic loci in DROSHA and ZNF91/LINC01224, with the latter replicating the findings in European ancestries.Gene-based association testing corroborates these findings.Interestingly, both genes are enriched in cerebellum, a key structure receiving sensory input from the vestibular system.

Subjects carrying risk alleles from lead SNPs of DROSHA and ZNF91 incur a 1.74-fold ill tempered gnome risk of vertigo than those without.Moreover, composite clinical-polygenic risk scores allow differentiation between patients and controls, yielding an area under receiver operating characteristic curve of 0.69.This study identified novel genomic loci for vertigo in an Asian population-based cohort, which may help identifying high risk subjects and provide mechanistic insight in understanding the pathogenesis of vertigo.